![]() ![]() The reason for this confusion revolves around whether we should regard two samples as independent (marginally) or not. Although this fact is well documented in statistical literature, confusion exists with regard to the use of these two test methods, resulting in their inappropriate use. If the data is normally distributed, the two-sample t-test (for two independent groups) and the paired t-test (for matched samples) are probably the most widely used methods in statistics for the comparison of differences between two samples. If the outcome data are continuous variables (such as blood pressure), the researchers may want to know whether there is a significant difference in the mean values between the two groups. The statistical methods used in the data analysis depend on the type of outcome. ![]() Let me know in the comments if you have any questions on $t$-test calculator for two means (unequal variances) with examples and your thought on this article.In clinical research, we usually compare the results of two treatment groups (experimental and control).
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